Role of the N-terminus of glutathione in the action of yeast glyoxalase I.

Direct Demonstration by H.N.M.R. spectrometry of the stereoselectivity of yeast Glyoxalase l towards the Diastereomeric forms of the a-ketoaldehyde - Glutathione Hemithioacetal

pH dependence of the inhibition of yeast glyoxalase 1 by prophyrins

The glutathione-dependent glyoxalase pathway in the yeast Saccharomyces cerevisiae.

Glyoxalase I (EC 4.4.1.5), which catalyzes the reaction methylglyoxal + GSH leads to S-lactoylglutathione, is a ubiquitous enzyme for which no clear physiological function has been shown. In the yeast Saccharomyces cerevisiae, methylglyoxal may derive from the spontaneous decay of intracellular glyceraldehyde-3-P, which may accumulate during growth on glycerol as the carbon source. The half-lif...

A glyoxalase I inhibitor of a new structural type produced by Streptomyces.

Many streptomyces strains produced an inhibitor of crude glyoxalase prepared from rat liver which did not inhibit glyoxalase I prepared from yeast. Another inhibitor, C11H14O6, which inhibited glyoxalases prepared from both rat liver and yeast was obtained from a cultured broth of Streptomyces griseosproeus and crystallized. Preincubation of this inhibitor with reuduced glutathione increased it...

Effect of Linalool on the Activity of Glyoxalase-I and Diverse Glycation Products in Rats with Type 2 Diabetes

Background and purpose: Hyperglycemia contributes to type 2 diabetes and diabetes vascular complications by reduction of the activity of glyoxalase-I (GLO-I) and elevation of glycation, oxidative stress, and inflammatory markers. Linalool is reported to have beneficial effects on glucose metabolism in animal models of diabetes, so, this study aimed at investigating the effect of linalool on the...